| Autor: |
Lotus L. van den Hoogen, Marije K. Verheul, Eric R. A. Vos, Cheyenne C. E. van Hagen, Michiel van Boven, Denise Wong, Alienke J. Wijmenga-Monsuur, Gaby Smits, Marjan Kuijer, Debbie van Rooijen, Marjan Bogaard-van Maurik, Ilse Zutt, Jeffrey van Vliet, Janine Wolf, Fiona R. M. van der Klis, Hester E. de Melker, Robert S. van Binnendijk, Gerco den Hartog |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Scientific Reports, Vol 12, Iss 1, Pp 1-6 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-022-10020-6 |
| Popis: |
Abstract mRNA- and vector-based vaccines are used at a large scale to prevent COVID-19. We compared Spike S1-specific (S1) IgG antibodies after vaccination with mRNA-based (Comirnaty, Spikevax) or vector-based (Janssen, Vaxzevria) vaccines, using samples from a Dutch nationwide cohort. In adults 18–64 years old (n = 2412), the median vaccination interval between the two doses was 77 days for Vaxzevria (interquartile range, IQR: 69–77), 35 days (28–35) for Comirnaty and 33 days (28–35) for Spikevax. mRNA vaccines induced faster inclines and higher S1 antibodies compared to vector-based vaccines. For all vaccines, one dose resulted in boosting of S1 antibodies in adults with a history of SARS-CoV-2 infection. For Comirnaty, two to four months following the second dose (n = 196), S1 antibodies in adults aged 18–64 years old (436 BAU/mL, IQR: 328–891) were less variable and median concentrations higher compared to those in persons ≥ 80 years old (366, 177–743), but differences were not statistically significant (p > 0.100). Nearly all participants seroconverted following COVID-19 vaccination, including the aging population. These data confirm results from controlled vaccine trials in a general population, including vulnerable groups. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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