| Autor: |
Francisco José Molina, Luz Elena Botero, Juan Pablo Isaza, Luz Elena Cano, Lucelly López, Lina Marcela Hoyos, Elizabeth Correa, Antoni Torres |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Frontiers in Medicine, Vol 9 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2296-858X |
| DOI: |
10.3389/fmed.2022.1005636 |
| Popis: |
BackgroundHigh levels of different cytokines have been associated in COVID-19 as predictors of mortality; however, not all studies have found this association and its role to cause multi-organ failure and death has not been fully defined. This study aimed to investigate the association of the levels of 10 cytokines with mortality in patients with COVID-19 admitted to the intensive care unit (ICU).Materials and methodsThis is a case-control study nested within a cohort of patients with COVID-19 who were on mechanical ventilation and were not hospitalized for more than 48 h across nine ICUs in Medellín, Colombia. Serum samples were collected upon admission to the ICU and 7 days later and used to measure cytokine levels.ResultsUpon admission, no differences in mortality between the cytokine levels were observed when comparisons were made quantitatively. However, in the multivariate analysis, patients with median IL-1β levels 1.666 pg/ml was associated with decreased survival. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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