| Autor: |
Chee H Ng, Gabor S Ungvari, Yu-Tao Xiang, Wei Zheng, Dong-Bin Cai, Xin-Hu Yang, Zhan-Ming Shi, Mei-Ling Hu, Yu-Ping Ning |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
General Psychiatry, Vol 32, Iss 5 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2517-729X |
| DOI: |
10.1136/gpsych-2019-100091 |
| Popis: |
Background Hyperprolactinaemia is a common antipsychotic (AP)-induced adverse effect, particularly in female patients.Aims This meta-analysis examined the efficacy and safety of adjunctive aripiprazole in preventing AP-related hyperprolactinaemia in patients with first-episode schizophrenia.Methods PubMed, PsycINFO, EMBASE, Cochrane Library, WanFang and China Journal Net databases were searched to identify eligible randomised controlled trials (RCTs). Primary outcomes were the reductions of serum prolactin level and prolactin-related symptoms. Data were independently extracted by two reviewers and analysed using RevMan (V.5.3). Weighted/standardised mean differences (WMDs/SMDs)±95% CIs were reported.Results In the five RCTs (n=400), the adjunctive aripiprazole (n=197) and the control groups (n=203) with a mean of 11.2 weeks of treatment duration were compared. The aripiprazole group had a significantly lower endpoint serum prolactin level in all patients (five RCTs, n=385; WMD: −50.43 ng/mL (95% CI: −75.05 to −25.81), p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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