Effects of diet-induced hypercholesterolemia and gold nanoparticles treatment on peripheral tissues

Autor: MATHEUS S. RODRIGUES, JULIA N. MARTINS, GABRIELA C. DE PAULA, LIGIA M. VENTURINI, GUSTAVO DE B. SILVEIRA, EMÍLIO L. STRECK, JOSIANI BUDNI, RICARDO A. MACHADO DE ÁVILA, ANDREZA F. DE BEM, PAULO C.L. SILVEIRA, JADE DE OLIVEIRA
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Anais da Academia Brasileira de Ciências, Vol 94, Iss suppl 4 (2022)
Druh dokumentu: article
ISSN: 1678-2690
0001-3765
DOI: 10.1590/0001-3765202220211081
Popis: Abstract Cholesterol is a lipid molecule of great biological importance to animal cells. Dysregulation of cholesterol metabolism leads to raised blood total cholesterol levels, a clinical condition called hypercholesterolemia. Evidence has shown that hypercholesterolemia is associated with the development of liver and heart disease. One of the mechanisms underlying heart and liver alterations induced by hypercholesterolemia is oxidative stress. In this regard, in several experimental studies, gold nanoparticles (AuNP) displayed antioxidant properties. We hypothesized that hypercholesterolemia causes redox system imbalance in the liver and cardiac tissues, and AuNP treatment could ameliorate it. Young adult male Swiss mice fed a regular rodent diet or a high cholesterol diet for eight weeks and concomitantly treated with AuNP (2.5 μg/kg) or vehicle by oral gavage. Hypercholesterolemia increased the nitrite concentration and glutathione (GSH) levels and decreased the liver’s superoxide dismutase (SOD) activity. Also, hypercholesterolemia significantly enhanced the reactive oxygen species (ROS) and GSH levels in cardiac tissue. Notably, AuNP promoted the redox system homeostasis, increasing the SOD activity in hepatic tissue and reducing ROS levels in cardiac tissue. Overall, our data showed that hypercholesterolemia triggered oxidative stress in mice’s liver and heart, which was partially prevented by AuNP treatment.
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