Synthesis and Antimicrobial Activity of 4-S-Methyl-1,3,4-Oxadiazole Derivatives of Some Natural Amino Acids Bearing Secondary Quaternary Ammonium Salt Moieties

Autor: Daoudi Sofiane, Ali Othman Adil, Benaissa Tahar, Adli Djallal Eddine
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Orbital: The Electronic Journal of Chemistry, Vol 10, Iss 7, Pp 482-488 (2018)
Druh dokumentu: article
ISSN: 1984-6428
DOI: 10.17807/orbital.v10i7.990
Popis: Secondary quaternary ammonium salts (QAS) derived from three natural amino acids (L-Leucine, L-Phenylalanine and L-Methionine) bearing 1,3,4-oxadiazole and acetic acid moieties have been synthesized and characterized by IR, 1H and 13C NMR. All the synthesized compounds were evaluated for their preliminary in vitro antibacterial and antifungal activity against different bacterial and fungal strains. All the synthesized compounds showed varying degrees of inhibition against the tested microorganisms. DOI: http://dx.doi.org/10.17807/orbital.v10i7.990
Databáze: Directory of Open Access Journals