Endometrial hyperplasia features in conditions of organic solvents exposure

Autor: I. O. Marinkin, L. A. Shpagina, E. S. Lisova, I. S. Shpagin, O. S. Kotova, G. V. Kuznetsova, E. M. Loktin, S. A. Karmanovskaya
Jazyk: English<br />Russian
Rok vydání: 2023
Předmět:
Zdroj: Медицинский вестник Юга России, Vol 13, Iss 4, Pp 28-38 (2023)
Druh dokumentu: article
ISSN: 2219-8075
2618-7876
DOI: 10.21886/2219-8075-2022-13-4-28-38
Popis: Objective: to establish clinical and molecular features of endometrial hyperplasia in conditions of organic solvents exposure in patients with obesity. Materials and methods: postmenopausal women with endometrial hyperplasia (morphological criteria) were included to observational cross-sectional study. The main group included 140 subjects with occupational organic solvents exposure, aged 57,5 (46;64) years, of whom 70 had obesity and 70 had normal weight. Comparison group — 140 women without of occupational health risks, aged 56,5 (46;65) years, 68 with and 72 without obesity. Investigated workers were painters in machine building industry with length of service above 10 years, in post-contact period lasted for 1-5 years were 29 (20.7%) of participants. Organic solvents concentrations at the workplace’s areas were 1.5-5.5 times above occupational exposure limits. Linear and logistic regression were used to explore relationships. Level of significance p
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