Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata
Autor: | Si-Yue Chen, Chang-An Geng, Yun-Bao Ma, Ji-Jun Chen |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: | |
Zdroj: | Natural Products and Bioprospecting, Vol 9, Iss 4, Pp 297-302 (2019) |
Druh dokumentu: | article |
ISSN: | 2192-2195 2192-2209 |
DOI: | 10.1007/s13659-019-0213-2 |
Popis: | Abstract Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1–3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT1 and MT2 receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC50 value of 76.24 μM on MT2 receptor. Graphic Abstract |
Databáze: | Directory of Open Access Journals |
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