Melatonin Receptors Agonistic Activities of Phenols from Gastrodia elata

Autor: Si-Yue Chen, Chang-An Geng, Yun-Bao Ma, Ji-Jun Chen
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Natural Products and Bioprospecting, Vol 9, Iss 4, Pp 297-302 (2019)
Druh dokumentu: article
ISSN: 2192-2195
2192-2209
DOI: 10.1007/s13659-019-0213-2
Popis: Abstract Gastrodia elata is a famous traditional Chinese herb with medicinal and edible application. In this study, three new polybenzyls, gastropolybenzylols G-I (1–3) were isolated from the EtOAc extract of G. elata. Their structures were identified by extensive spectroscopic analyses involving HRESIMS, UV, IR, 1D and 2D NMR. Compound 1 showed agonistic effects on MT1 and MT2 receptors with agonistic rates of 55.91±4.84% and 165.13±5.65% at the concentration of 0.5 mM, respectively, and an EC50 value of 76.24 μM on MT2 receptor. Graphic Abstract
Databáze: Directory of Open Access Journals
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