| Autor: |
Hiroko Suzuki, Naho Morisaki, Saori Nagashima, Tamotsu Matsunaga, Shoko Matsushita, Akira Iino, Yuichiro Tanaka, Hisashi Nishimori, Shun Munakata, Manabu Kemmochi, Yoshitaka Murakami, Miori Sato, Kenji Toyokuni, Kiwako Yamamoto-Hanada, Hideaki Morita, Tatsuki Fukuie, Yoshiyuki Yamada, Yoshikazu Ohtsuka, Katsuhiro Arai, Yukihiro Ohya, Hirohisa Saito, Kenji Matsumoto, Ichiro Nomura |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Allergology International, Vol 73, Iss 2, Pp 264-274 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1323-8930 |
| DOI: |
10.1016/j.alit.2023.10.003 |
| Popis: |
Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GIFAs) seem to be increasing rapidly worldwide. However, nationwide studies have been limited to food-protein-induced enterocolitis (FPIES) and food-protein-induced allergic proctocolitis (FPIAP), with little attention to other non-IgE-GIFA subgroups. The aim of this study was to elucidate the clinical features of all patients with non-IgE-GIFAs, not just certain subgroups. Methods: We conducted a nationwide cross-sectional survey of non-IgE-GIFAs in Japan from April 2015 through March 2016. A questionnaire was sent to hospitals and clinics throughout Japan. The questionnaire asked about the number of physician-diagnosed non-IgE-GIFA patients, the status of fulfillment of the diagnostic criteria, tentative classification into 4 clusters based on the initial symptoms, the day of onset after birth, complications, and the suspected offending food(s). Results: The response rate to that questionnaire was 67.6% from hospitals and 47.4% from clinics. Analyses were conducted about “diagnosis-probable” patient cohort (n = 402) and the “diagnosis-confirmed” patients (n = 80). In half of the reported non-IgE-GIFA patients, onset occurred in the neonatal period. The patients were evenly distributed among 4 non-IgE-GIFA clusters. In Cluster 1, with symptoms of vomiting and bloody stool, the onset showed a median of 7 days after birth, which was the earliest among the clusters. Cow's milk was the most common causative food. Conclusions: In half of the patients, the onset of non-IgE-GIFAs was in the neonatal period. This highlights the importance of studying the pathogenesis in the fetal and neonatal periods. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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