Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects

Autor: Gustavo Grossi-Oliveira, Leonardo P. Faverani, Bruno Coelho Mendes, Tárik Ocon Braga Polo, Gabriel Cury Batista Mendes, Valthierre Nunes de Lima, Paulo Domingos Ribeiro Júnior, Roberta Okamoto, Osvaldo Magro-Filho
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Biomaterials, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 1687-8787
1687-8795
66155657
DOI: 10.1155/2020/5182845
Popis: This study evaluated the osteoconductive potential of four biomaterials used to fill bone defects. For this, 24 male Albino rabbits were submitted to the creation of a bilateral 8 mm calvarial bone defect. The animals were divided into four groups—bovine hydroxyapatite, Bio-Oss® (BIO); Lumina-Bone Porous® (LBP); Bonefill® (BFL); and an alloplastic material, Clonos® (CLN)—and were euthanized at 14 and 40 days. The samples were subjected to histological and histometric analysis for newly formed bone area. Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed. After statistical analysis, the CLN group showed greater new bone formation (NB) in both periods analyzed (p
Databáze: Directory of Open Access Journals
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