New CAPA-dependent Cystatin C Equation: increased detection of decreased glomerular filtration in HIV-infected patients
| Autor: | Albertina M. Ghelfi, María Rosa Galván, Fabián Fay, Jorgelina N. Herrera, Fernando Elías, Hernán Brescia, Juan A. Rossi, Jorge O. Galíndez |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Revista de Nefrología, Diálisis y Trasplante, Vol 38, Iss 3, Pp 187-198 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0326-3428 2346-8548 |
| Popis: | Introduction: Creatinine and its equations have clear limitations regarding their low sensitivity to identify initial stages of renal dysfunction. Cystatin C has been proposed as a promising marker, but so far, there has been no evidence showing the superiority of its equations over the creatinine ones. However, there are no studies which compare the performance of the latest cystatin equation developed by Grubb and collaborators in 2014: the “CAPA” equation. Objectives: To analyze the performance of CAPA equation to detect early reduction of glomerular filtration in HIV-infected patients, in comparison with creatinine-dependent equations: Cockroft-Gault, MDRD-4, CKD-EPI and MCQ. Methods: An analytical, observational, cross-sectional study was conducted between July and November 2017, at an Argentinian specialty hospital. ≥18-year old HIV-infected patients undergoing antiretroviral therapy were included. Cases with creatinine ≥1.2 mg/dL were excluded. Results: 100 patients were recruited, and 89 were included: 47 (52.8%) were women. CAPA equation detected more pronounced decreases in GFR than the creatinine-dependent equations. The mean values of GFR obtained by CAPA showed differences with the ones found through Cockroft-Gault (p |
| Databáze: | Directory of Open Access Journals |
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