Association between the 110‐kDa C‐terminal agrin fragment and skeletal muscle decline among community‐dwelling older women

Autor: Kuniyasu Kamiya, Takahiro Tachiki, Yuho Sato, Katsuyasu Kouda, Etsuko Kajita, Junko Tamaki, Sadanobu Kagamimori, Masayuki Iki
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Cachexia, Sarcopenia and Muscle, Vol 14, Iss 5, Pp 2253-2263 (2023)
Druh dokumentu: article
ISSN: 2190-6009
2190-5991
DOI: 10.1002/jcsm.13309
Popis: Abstract Background C‐terminal agrin fragment (CAF) is a biomarker for neuromuscular junction degradation. This study aimed to investigate whether 110‐kDa CAF (CAF110) was associated with the presence and incidence of low muscle mass and strength. Methods This cross‐sectional retrospective cohort study comprised women aged ≥65 years. We measured muscle mass using a dual‐energy X‐ray absorptiometry scanner, hand‐grip strength, and blood sampling between 2011 and 2012. A follow‐up study with the same measurements was conducted between 2015 and 2017. Low muscle mass and strength were defined as an appendicular skeletal muscle mass index
Databáze: Directory of Open Access Journals
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