Chemoreactome analysis of 7-hydroxymatairesinol, 17-estradiol, phytoestrogen β-sitosterol and epigallocatechin-3-gallate

Autor:	I. Yu. Torshin, A. N. Rubashkina, N. P. Lapochkina, O. A. Gromova
Jazyk:	ruština
Rok vydání:	2020
Předmět:	7-hydroxymatairesinol spruce lignans 17-estradiol β-sitosterol phytoestrogen epigallocatechin-3-gallate chemoreactome analysis Gynecology and obstetrics RG1-991
Zdroj:	Акушерство, гинекология и репродукция, Vol 14, Iss 3, Pp 347-360 (2020)
Druh dokumentu:	article
ISSN:	2313-7347 2500-3194
DOI:	10.17749/2313-7347/ob.gyn.rep.2020.152
Popis:	The results of the evaluation of 7-hydroximatairesinol (7-HMR) properties in comparison with control molecules (17-estradiol, phytoestrogen β-sytostirol, epigallocatechin-3-gallate) are presented. The results of chemoreactomic modeling allowed to formulate the molecular mechanisms of 7-HMR pharmacological effects for anti-inflammatory (inhibition of 5-lipoxygenase, matrix metalloproteinase MMR2, mitogen-activated kinase p38-alpha, leukotriene-b4 receptor, prostacyclin receptor), antitumor (antioxidant effect due to inhibition of hemoxygenase-2, inhibition of cyclin dependent kinases 3 and 4, epidermis growth factor, protein mTOR), vasodilator (inhibition of adrenoreceptors and renin), antibacterial and antiviral (inhibition of viral proteases 3C) properties of 7-HMR molecule.
Databáze:	Directory of Open Access Journals
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