Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

Autor:	Milad Ashrafizadeh, Mahshid Deldar Abad Paskeh, Sepideh Mirzaei, Mohammad Hossein Gholami, Ali Zarrabi, Farid Hashemi, Kiavash Hushmandi, Mehrdad Hashemi, Noushin Nabavi, Francesco Crea, Jun Ren, Daniel J. Klionsky, Alan Prem Kumar, Yuzhuo Wang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Anti-tumor compounds Autophagy Biomarker Non-coding RNAs Prostate cancer Therapy response Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-37 (2022)
Druh dokumentu:	article
ISSN:	1756-9966
DOI:	10.1186/s13046-022-02293-6
Popis:	Highlights • Prostate cancer is among the leading causes of death in men where targeting autophagy is of importance in treatment; • Autophagy governs proliferation and metastasis capacity of prostate cancer cells; • Autophagy modulation is of interest in improving the therapeutic response of prostate cancer cells; • Molecular pathways, especially involving non-coding RNAs, regulate autophagy in prostate cancer; • Autophagy possesses both diagnostic and prognostic roles in prostate cancer, with promises for clinical application.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/15dbdef019a24ab4ac3b0027403386c3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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