| Autor: |
Alain Brunet, Ram P. Sapkota, Bhushan Guragain, Jacques Tremblay, Daniel Saumier, Laurence J. Kirmayer |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMC Psychiatry, Vol 21, Iss 1, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1471-244X |
| DOI: |
10.1186/s12888-021-03441-6 |
| Popis: |
Abstract Background Traumatic stress is a global mental health problem requiring novel, easily implemented treatment solutions. We compared the effectiveness and efficiency of Reconsolidation Therapy (RT) to the well-established antidepressant paroxetine, in reducing symptoms of traumatic stress among patients from Nepal, a low-income country. Methods Forty-six adults with posttraumatic stress disorder (PTSD) were randomized to one of two groups. The reconsolidation blocker propranolol was administered 90 min before briefly recalling a traumatic memory with a therapist, weekly for six consecutive weeks. This was compared to daily paroxetine for 26 weeks. Self-reported PTSD symptoms were assessed blindly at the 7th, 13th, and 26th weeks. Results An intent-to-treat analysis revealed a robust pre- to post-treatment main effect (β 1 = − 4.83, 95% CI = [− 5.66, − 4.01], p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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