Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure

Autor:	Yuji Nozaki, Akiomi Yoshihisa, Yu Sato, Himika Ohara, Yukiko Sugawara, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Kazuhiko Nakazato, Yasuchika Takeishi
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	hypochloremia serum chloride heart failure cardiac death all-cause death Medicine
Zdroj:	Journal of Clinical Medicine, Vol 12, Iss 4, p 1257 (2023)
Druh dokumentu:	article
ISSN:	2077-0383
DOI:	10.3390/jcm12041257
Popis:	Background: Hypochloremia reflects neuro-hormonal activation in patients with heart failure (HF). However, the prognostic impact of persistent hypochloremia in those patients remains unclear. Methods: We collected the data of patients who were hospitalized for HF at least twice between 2010 and 2021 (n = 348). Dialysis patients (n = 26) were excluded. The patients were divided into four groups based on the absence/presence of hypochloremia (p < 0.001) and cardiac death (hazard ratio 3.919, p < 0.001). Conclusions: In patients with HF, prolonged hypochloremia over two hospitalizations is associated with an adverse prognosis.
Databáze:	Directory of Open Access Journals
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