Minimal Diversity of Drug-Resistant Mycobacterium tuberculosis Strains, South Africa

Autor: Neel R. Gandhi, James C.M. Brust, Prashini Moodley, Darren Weissman, Moonseong Heo, Yuming Ning, Anthony P. Moll, Gerald H. Friedland, A. Willem Sturm, N. Sarita Shah
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Emerging Infectious Diseases, Vol 20, Iss 3, Pp 394-401 (2014)
Druh dokumentu: article
ISSN: 1080-6040
1080-6059
DOI: 10.3201/eid2003.131083
Popis: Multidrug- (MDR) and extensively drug-resistant tuberculosis (XDR TB) are commonly associated with Beijing strains. However, in KwaZulu-Natal, South Africa, which has among the highest incidence and mortality for MDR and XDR TB, data suggest that non-Beijing strains are driving the epidemic. We conducted a retrospective study to characterize the strain prevalence among drug-susceptible, MDR, and XDR TB cases and determine associations between strain type and survival. Among 297 isolates from 2005–2006, 49 spoligotype patterns were found. Predominant strains were Beijing (ST1) among drug-susceptible isolates (27%), S/Quebec (ST34) in MDR TB (34%) and LAM4/KZN (ST60) in XDR TB (89%). More than 90% of patients were HIV co-infected. MDR TB and XDR TB were independently associated with mortality, but TB strain type was not. We conclude that, although Beijing strain was common among drug-susceptible TB, other strains predominated among MDR TB and XDR TB cases. Drug-resistance was a stronger predictor of survival than strain type. Download MP3 Length: 1:50
Databáze: Directory of Open Access Journals
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