Successful Response of Pembrolizumab Rechallenge after Radiotherapy for a Patient with Bladder Cancer of Nonresponse of Pembrolizumab First Challenge

Autor: Taro Ikeda, Go Hasegawa, Gen Kawaguchi, Yohei Ikeda, Noboru Hara, Tsutomu Nishiyama
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Case Reports in Urology, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 2090-696X
2090-6978
DOI: 10.1155/2021/9087529
Popis: We report a patient with advanced bladder cancer in which the primary lesion and metastatic site disappeared following the pembrolizumab therapy rechallenge after radiotherapy for bladder cancer lesion of nonresponse of pembrolizumab first challenge. A 76-year-old man with advanced bladder cancer received three courses of the chemotherapy with gemcitabine and cisplatin combination; however, the chemotherapy was stopped because of adverse events. The patient started pembrolizumab therapy; however, the effect was not observed. Radiation therapy was given to the primary lesion and pelvic lymph node metastases for the purpose of local control of the lesions. Because the primary lesion was regrowth and para-aortic lymph node metastasis appeared, pembrolizumab therapy was resumed. Thereafter, the primary lesion and metastatic site disappeared.
Databáze: Directory of Open Access Journals
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