RETRACTED ARTICLE: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and their association with the disease severity and activity

Autor: Ahmed Al Qteishat, Kiril Kirov, Dmitry Bokov
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Gastroenterology, Vol 22, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1471-230X
DOI: 10.1186/s12876-022-02562-w
Popis: Abstract Background The epidemiology of Crohn’s disease (CD) has changed over the past decades, demonstrating a trend toward increased prevalence in developing countries, while in developed countries, its incidence has stabilized. The study aimed to examine the profile of the key pro-inflammatory cytokines in the serum of patients with CD and establish their association with the severity and activity of the disease. Methods A total of 61 patients (29 women (47.5%), 32 men (52.5%) aged from 18 to 40 years (mean age (30.42 ± 2.51) years) with the verified diagnosis of CD in the active phase were examined. The control group consisted of 30 healthy people of corresponding age. Results CD is characterized by a reliable increase of pro-inflammatory cytokines in blood compared to healthy people: tumor necrosis factor-α (TNF-α) – by 4.45 times (137.46 ± 9.72 vs. 30.88 ± 2.08 pg/ml in healthy people, p
Databáze: Directory of Open Access Journals
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