11-Hydroxy-7-Methoxy-2,8-Dimethyltetracene-5,12-Dione

Autor:	Rishi Vachaspathy Astakala, Gagan Preet, Ahlam Haj Hasan, Ria Desai, Juan A. Asenjo, Barbara Andrews, William T. A. Harrison, Rainer Ebel, Marcel Jaspars
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Atacama Desert actinobacteria Saccharothrix X-ray crystallography anthracyclines Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2024, Iss 2, p M1822 (2024)
Druh dokumentu:	article
ISSN:	1422-8599 43996116
DOI:	10.3390/M1822
Popis:	Microorganisms are a valuable source of pharmaceutically active chemicals, serving as scaffolds for synthesis as well as lead structures. Investigating novel biomes frequently yields intriguing chemistry; the Atacama Desert in Chile is one such example. This study reports the isolation of a new reduced anthracycline-related compound from the Atacama Desert-derived bacterium Saccharothrix S26. Structural characterisation was achieved by one-dimensional and two-dimensional NMR, HR-LCMS, and X-ray crystallography. The compound was tested against the ESKAPE pathogens, bovine mastitis-related pathogens, and the fungal strain Cryptococcus neoformans, but no antimicrobial activity was observed.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/15a6faa331ac4d7a82c43996116937f3 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.