Proton pump inhibitor usage is associated with higher all-cause mortality and CV events in peritoneal dialysis patients

Autor: Yingsi Zeng, Lingling Liu, Liya Zhu, Xiaojiang Zhan, Fenfen Peng, Xiaoran Feng, Qian Zhou, Yujing Zhang, Zebin Wang, Jianbo Liang, Jiao Li, Yueqiang Wen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Renal Failure, Vol 44, Iss 1, Pp 407-414 (2022)
Druh dokumentu: article
ISSN: 0886022X
1525-6049
0886-022X
DOI: 10.1080/0886022X.2022.2043903
Popis: Objectives A long period of inappropriate proton pump inhibitors (PPI) treatment has been proved to be associated with adverse prognosis in general population and hemodialysis patients. This study was conducted to clarify the impact of PPI usage on mortality and adverse cardiovascular (CV) events in peritoneal dialysis (PD) patients.Methods and design This is a retrospective study. A total of 905 patients were enrolled from two PD centers, including 211 patients on PPI treatment and 618 patients not on PPIs. Kaplan–Meier curves were used to identify the incidence of adverse outcomes. Multivariate Cox regression models and inverse probability of treatment weighting (IPTW) were applied to analyze hazard ratios (HRs) for adverse outcomes.Results During follow-up, 162 deaths and 102 CV events were recorded. Kaplan–Meier curve demonstrated all-cause mortality (log-rank test p = .018) and CV events (log-rank test p = .024) were significantly higher in PPI usage group. Multivariate Cox regression models and IPTW showed that PPI usage was an indicator for all-cause mortality (HR = 1.35, 95%CI = 1.09–1.67, p = .006) and CV events (HR = 1.78, 95%CI = 1.35–2.32, p
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