| Autor: |
Jorge Luiz Dantas de Medeiros, Bruno Carneiro Bezerra, Helen Rainara Araújo Cruz, Katarina Azevedo de Medeiros, Maria Eduarda Cardoso de Melo, Aquiles Sales Craveiro Sarmento, Marcela Abbott Galvão Ururahy, Lucymara Fassarella Agnez Lima, Alcebíades José dos Santos Neto, Josivan Gomes Lima, Vanessa Resqueti, Lucien Peroni Gualdi, Guilherme Fregonezi, Julliane Tamara Araújo de Melo Campos |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
BMC Cardiovascular Disorders, Vol 22, Iss 1, Pp 1-14 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2261 |
| DOI: |
10.1186/s12872-022-02828-x |
| Popis: |
Abstract Background Congenital Generalized Lipodystrophy (CGL) is an ultra-rare disease characterized by metabolic disorders. However, the evaluation of functional exercise capacity, cardiovascular (CV) response to exercise, and peripheral arterial disease (PAD) in CGL is scarce. Here we evaluated the performance and CV response to exercise and their association with PAD in CGL compared to healthy individuals. Methods Twelve CGL and 12 healthy subjects matched for age and gender were included. Functional exercise capacity, CV response, and PAD were measured using the six-minute walk test (6MWT) and ankle-brachial index (ABI), respectively. Results At baseline, CGL subjects showed reduced predicted walked distance (6MWD) (p = 0.009) and increased heart rate (HR), systolic (SBP), and diastolic (DBP) pressures compared to healthy subjects (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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