Nephrotic Syndrome as a Cause of Transient Clinical Hypothyroidism

Autor: Vânia Benido Silva, Maria Teresa Pereira, Carla Leal Moreira, Sílvia Santos Monteiro, Isabel Inácio, Maria Helena Cardoso
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Case Reports in Endocrinology, Vol 2021 (2021)
Druh dokumentu: article
ISSN: 2090-6501
2090-651X
DOI: 10.1155/2021/5523929
Popis: Nephrotic syndrome may trigger the onset of hypothyroidism, promoting massive urinary protein losses including thyroxine (T4) and triiodothyronine (T3) along with their binding proteins. At an early stage, a clinical and biochemical euthyroid state is expected. However, in patients with prolonged and severe proteinuria, especially with concomitant low thyroid reserve, urinary losses of free and protein-bound thyroid hormones are sufficiently pronounced to induce a subclinical or overt hypothyroidism. Despite its high prevalence in clinical practice, the literature lacks case reports of newly diagnosed clinical hypothyroidism due to NS in adults, making this condition under-recognized. We report a case of a 23-year-old man with previous normal thyroid function who developed overt hypothyroidism due to a severe nephrotic syndrome, requiring supplementation with levothyroxine (LT). After the patient had undergone bilateral nephrectomy, treatment with LT was discontinued and thyroid function normalized.
Databáze: Directory of Open Access Journals
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