Medication exposure and predictors of first mood episode in offspring of parents with bipolar disorder: a prospective study
| Autor: | Fabiano G. Nery, Anna R. Wilson, Marguerite R. Schneider, Jeffrey R. Strawn, Luis R. Patino, Robert K. McNamara, Caleb M. Adler, Stephen M. Strakowski, Melissa P. DelBello |
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| Jazyk: | English<br />Portuguese |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Brazilian Journal of Psychiatry, Vol 42, Iss 5, Pp 481-488 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1809-452X 1516-4446 |
| DOI: | 10.1590/1516-4446-2019-0802 |
| Popis: | Objectives: To prospectively investigate whether baseline clinical characteristics and medication exposure predict development of major depressive disorder or bipolar disorder in offspring of parents with bipolar disorder. Methods: Youth aged 9-20 years with at least one biological parent with bipolar disorder and no prior history of mood or psychotic episodes (n=93) were prospectively evaluated and treated naturalistically during the study. Participants were divided into two groups: converters, defined as those who met DSM-IV criteria for a mood episode during follow-up (n=19); or non-converters (n=74). Logistic regression models were used to investigate associations between baseline clinical variables and medication exposure during follow-up and risk of developing a first mood episode (conversion). Results: Multivariate regression analyses showed that baseline anxiety disorders and subsyndromal mood disorders were associated with increased risk of conversion during follow-up. Adding medication exposure to the multivariate model showed that exposure to antidepressants during follow-up was associated with increased risk of conversion. Conclusions: Caution should be used when treating bipolar offspring with anxiety and/or emerging depressive symptoms using antidepressant agents, given the increased risk of developing a major mood disorder. |
| Databáze: | Directory of Open Access Journals |
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