Screening of the siGPCR library in combination with cisplatin against lung cancers

Autor: Youngju Kim, Jieun Lee, Sumin Jeong, Woo-Young Kim, Euna Jeong, Sukjoon Yoon
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-022-21063-0
Popis: Abstract The screening of siRNAs targeting 390 human G protein-coupled receptors (GPCRs) was multiplexed in combination with cisplatin against lung cancer cells. While the cell viability measure hardly captured the anticancer effect of siGPCRs, the direct cell count revealed the anticancer potential of diverse GPCRs (46 hits with > twofold growth inhibition, p-value
Databáze: Directory of Open Access Journals
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