CYTOKINES AND FUNCTIONAL RESERVES OF ENDOTHELIUM IN PATIENTS WITH RESISTANT ARTERIAL HYPERTENSION
| Autor: | A. V. Safronenko |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Медицинский вестник Юга России, Vol 0, Iss 2, Pp 102-105 (2013) |
| Druh dokumentu: | article |
| ISSN: | 2219-8075 2618-7876 |
| DOI: | 10.21886/2219-8075-2013-2-102-105 |
| Popis: | Purpose: To evaluate the cytokine profile and endothelial functional reserve in patients with ref-teristic hypertension.Materials and methods: 42 patients with refractory hypertension (30 men and 12 women), control group - 32 patients. The average age of 59,4 ± 1,12 years. The metabolic stability of endothelium in patients evaluated in the study are pharmacologically tentsiiruemoy endothelium-dependent vasodilation (EDVD). The work has been defined as the original content in the blood of proinflammatory and anti-inflammatory cytokines.Results: It was found that in 66.7% of cases, metabolic stability endothelial cells to oxidative stress product is preserved, and in 33.3% of a loss of resistance to cytotoxic products.Conclusion: In patients with refractory hypertension without metabolic stability of endothelium-dependent vasodilation Leah ability vessels progressively reduced, which is associated with the increase in the level of pro-inflammatory cytokines in the blood. |
| Databáze: | Directory of Open Access Journals |
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