Interactive effects of molecular subtypes with tumor size and extracranial metastatic pattern on risk of brain metastasis in breast cancer patients: A population‐based study

Autor:	Bo Shen, Jieqing Li, Mei Yang, Kangkang Liu, Junsheng Zhang, Weiping Li, Yi Zhang, Kun Wang
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	brain metastasis breast cancer extracranial metastasis interaction analysis molecular subtype tumor size Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 12, Iss 6, Pp 6547-6557 (2023)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.5425
Popis:	Abstract Background Early detection of brain metastasis (BM) is essential for prognostic improvement in breast cancer (BC) patients. The aim was to identify predictors of BCBM in different molecular subtypes on a population‐based level. Methods The Surveillance, Epidemiology, and End Results database was used to select BC patients diagnosed from 2010 to 2018. We evaluated the incidence and risk factors of BCBM and tested the interaction effects between molecular subtypes and other risk factors. Results Among the 527,525 selected patients, molecular subtypes significantly interacted with T stage and extracranial metastasis (ECM) patterns on the risk of BM in the whole BC population (interaction p = 0.002,
Databáze:	Directory of Open Access Journals
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