| Autor: |
Lili Chen, Valentina Strohmeier, Zhengxiang He, Madhura Deshpande, Jovani Catalan-Dibene, Scott K. Durum, Thomas M. Moran, Thomas Kraus, Huabao Xiong, Jeremiah J. Faith, Chhinder P. Sodhi, David J. Hackam, Sergio A. Lira, Glaucia C. Furtado |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-019-12540-8 |
| Popis: |
Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22, which directly suppresses pancreatic cell differentiation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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