Clinical characteristics and prognostic significance of extramedullary involvement in childhood acute myeloid leukemia
| Autor: | A. K. Ignatova, I. I. Kalinina, D. A. Venev, T. Yu. Salimova, D. A. Evseev, M. N. Sadovskaya, O. V. Goronkova, V. E. Matveev, U. N. Petrova, K. S. Antonova, D. D. Baydildina, M. E. Dubrovnaya, T. V. Konyukhova, Yu. V. Olshanskaya, D. S. Abramov, M. A. Maschan, G. A. Novichkova, A. A. Maschan |
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| Jazyk: | ruština |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Онкогематология, Vol 16, Iss 1, Pp 10-22 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1818-8346 2413-4023 24523992 |
| DOI: | 10.17650/1818-8346-2021-16-1-10-22 |
| Popis: | Background. Extramedullary infiltration (EI) is relatively common in children with acute myeloid leukemia (AML) (up to 20-25 %). However, its clinical and prognostic significance remains poorly understood.Objective: to describe clinical features and to define prognostic significance of EI in children with AML.Materials and methods. The subjects of retrospective observational study were 228 children with de novo AML. The median age was 6.6 years. All of them were treated according to the protocol AML-MM-2006 from April 2007 to June 2018.All patients with EI were divided into three cohorts according to the localization of the lesions: 1) central nervous system (CNS) involvement (CNS group), 2) other localizations apart from CNS (myelosarcomas (MS) group), 3) combined lesions (CNS + MS group).Results. EI was diagnosed in 84 patients (36.84 %) with de novo AML. Among them 47 (55.95 %) had CNS involvement, 20 (23.81 %) had MS, 15 (17.86 %) had both CNS involvement and MS. 5-year overall survival (OS) rate was slightly higher in patients with CNS involvement than in children without EI - 80 ± 12 % vs 71 ± 9 %, p = 0.26, however OS in patients with MS was significantly lower - 45 ± 16 % vs 71 ± 9 %, p |
| Databáze: | Directory of Open Access Journals |
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