| Autor: |
Benjamin Deniau, Alice Blet, Karine Santos, Prabakar Vaittinada Ayar, Magali Genest, Mandy Kästorf, Malha Sadoune, Andreia de Sousa Jorge, Jane Lise Samuel, Nicolas Vodovar, Andreas Bergmann, Alexandre Mebazaa, Feriel Azibani |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 15, Iss 8, p e0238039 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0238039 |
| Popis: |
Sepsis is a global economic and health burden. Dipeptidyl peptidase 3 (DPP3) is elevated in the plasma of septic patients. The highest levels of circulating DPP3 (cDPP3) are found in non-survivor septic shock patients. The aim of this study was to evaluate the benefits of inhibiting cDPP3 by a specific antibody, Procizumab (PCZ), on cardiac function in an experimental model of sepsis, the caecal ligature and puncture (CLP) model. Rats were monitored by invasive blood pressure and echocardiography. Results are presented as mean ± SD, with p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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