| Autor: |
Awanti Sambarey, Abhinandan Devaprasad, Priyanka Baloni, Madhulika Mishra, Abhilash Mohan, Priyanka Tyagi, Amit Singh, JS Akshata, Razia Sultana, Shashidhar Buggi, Nagasuma Chandra |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
npj Systems Biology and Applications, Vol 3, Iss 1, Pp 1-12 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2056-7189 |
| DOI: |
10.1038/s41540-017-0005-4 |
| Popis: |
Tuberculosis: an underlying common-core host response network Patients suffering from tuberculosis (TB) show a high extent of variations in their gene expression patterns. Such heterogeneity poses major road blocks to our understanding of how hosts respond to the disease. A number of studies have profiled transcriptomes of human blood samples from TB patients, but a meta-analysis indicates that very few changes are consistently seen. The problem, to a large extent, lies with the way large data is analysed. We have used a genome-wide network approach to characterise the host response and have identified a common-core in the TB response networks of different patients, indicating the presence of unified host response mechanisms. This core network provides a comprehensive view into the most significant regulators of the infection-mediated biological processes across patients from different populations, and it shows partial reversals upon treatment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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