| Autor: |
René van Es, Maurits K. Konings, Bastiaan C. Du Pré, Kars Neven, Harry van Wessel, Vincent J. H. M. van Driel, Albert H. Westra, Pieter A. F. Doevendans, Fred H. M. Wittkampf |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BioMedical Engineering OnLine, Vol 18, Iss 1, Pp 1-13 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1475-925X |
| DOI: |
10.1186/s12938-019-0693-7 |
| Popis: |
Abstract Background Irreversible electroporation (IRE) using direct current (DC) is an effective method for the ablation of cardiac tissue. A major drawback of the use of DC-IRE, however, are two problems: requirement of general anesthesia due to severe muscle contractions and the formation of bubbles containing gaseous products from electrolysis. The use of high-frequency alternating current (HF-IRE) is expected to solve both problems, because HF-IRE produces little to no muscle spasms and does not cause electrolysis. Methods In the present study, we introduce a novel asymmetric, high-frequency (aHF) waveform for HF-IRE and present the results of a first, small, animal study to test its efficacy. Results The data of the experiments suggest that the aHF waveform creates significantly deeper lesions than a symmetric HF waveform of the same energy and frequency (p = 0.003). Conclusion We therefore conclude that the use of the aHF enhances the feasibility of the HF-IRE method. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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