| Autor: |
Anders Funkquist, Anders Bengtsson, P.M. Johansson, Johan Svensson, Per Bjellerup, Kaj Blennow, Birger Wandt, Stefan Sjöberg |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Journal of Clinical & Translational Endocrinology, Vol 19, Iss , Pp - (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2214-6237 |
| DOI: |
10.1016/j.jcte.2020.100218 |
| Popis: |
Background & Objective: Patients with mild hypothyroidism often are depressed and have impaired quality of life despite serum free-T4 and T3 within reference values. Therefore, we investigated whether their symptoms were dependent on the concentrations of free -T4 and T3 in the circulation and cerebrospinal fluid (CSF). Methods: Twenty-five newly diagnosed, untreated hypothyroid subjects and as many age- and sex-matched healthy controls were investigated. Blood and CSF sampling was performed in the morning after an overnight fast. Quality of life (QoL) was assessed by a Likert scale. In the hypothyroid subjects, the MADRS rating scale was also used to evaluate symptoms of depression. Furthermore, the results obtained by the questionnaires were related to serum and CSF levels of free- T4 and T3 as well as the ratios between them in CSF and in serum. Results: Self-reported health was considerably lower in hypothyroid subjects. MADRS was considerably higher than the normal range for healthy individuals. Low CSF/serum free-T4 ratio was correlated with an increased depressed state according to MADRS (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
