Dexmedetomidine as a Short-Use Analgesia for the Immature Nervous System

Autor: Anatoliy Logashkin, Valentina Silaeva, Arsen Mamleev, Viktoria Shumkova, Violetta Sitdikova, Yaroslavna Popova, Dmitrii Suchkov, Marat Minlebaev
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: International Journal of Molecular Sciences, Vol 25, Iss 12, p 6385 (2024)
Druh dokumentu: article
ISSN: 25126385
1422-0067
1661-6596
DOI: 10.3390/ijms25126385
Popis: Pain management in neonates continues to be a challenge. Diverse therapies are available that cause loss of pain sensitivity. However, because of side effects, the search for better options remains open. Dexmedetomidine is a promising drug; it has shown high efficacy with a good safety profile in sedation and analgesia in the immature nervous system. Though dexmedetomidine is already in use for pain control in neonates (including premature neonates) and infants as an adjunct to other anesthetics, the question remains whether it affects the neuronal activity patterning that is critical for development of the immature nervous system. In this study, using the neonatal rat as a model, the pharmacodynamic effects of dexmedetomidine on the nervous and cardiorespiratory systems were studied. Our results showed that dexmedetomidine has pronounced analgesic effects in the neonatal rat pups, and also weakly modified both the immature network patterns of cortical and hippocampal activity and the physiology of sleep cycles. Though the respiration and heart rates were slightly reduced after dexmedetomidine administration, it might be considered as the preferential independent short-term therapy for pain management in the immature and developing brain.
Databáze: Directory of Open Access Journals
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