Methylation of HPV16 and EPB41L3 in oral gargles and the detection of early and late oropharyngeal cancer

Autor:	Brittney L. Dickey, Belinda Nedjai, Matthew D. Preece, Michael J. Schell, David Boulware, Junmin Whiting, Bradley Sirak, Martha Abrahamsen, Kimberly A. Isaacs‐Soriano, Kayoko Kennedy, Christine H. Chung, Anna R. Giuliano
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	early detection HPV methylation oropharyngeal cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 11, Iss 20, Pp 3735-3742 (2022)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.4757
Popis:	Abstract As oropharyngeal cancer (OPC) associated with human papillomavirus (HPV) increases in men, the need for a screening test to diagnose OPC early is crucial. While HPV‐associated OPC has a favorable prognosis, recurrence is likely, and metastatic OPC is often incurable regardless of HPV status. Our previous study of pretreatment, male OPC cases (n = 101) and age‐ and smoking‐matched controls (n = 101) found methylation of the host EPB41L3 tumor suppressor gene and HPV16 in the oral gargle was correlated with these biomarkers in the tumor. Methylation of these genes in the oral gargle was significantly (p
Databáze:	Directory of Open Access Journals
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