| Autor: |
Joanna J. Sajkowska, Choi Har Tsang, Paweł Kozielewicz |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
SLAS Discovery, Vol 29, Iss 6, Pp 100174- (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2472-5552 |
| DOI: |
10.1016/j.slasd.2024.100174 |
| Popis: |
Bioluminescence- and fluorescence-based resonance energy transfer assays have gained considerable attention in pharmacological research as high-throughput scalable tools applicable to drug discovery. To this end, G protein-coupled receptors represent the biggest target class for marketed drugs, and among them, orphan G protein-coupled receptors have the biggest untapped therapeutic potential. In this review, the cases where biophysical methods, BRET and FRET, were employed for deorphanization and ligand discovery studies on orphan G protein-coupled receptors are listed and discussed. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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