| Autor: |
Mei Bou Nasif, Shweta Varade, Mohamad Z. Koubeissi |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Clinical Neurophysiology Practice, Vol 6, Iss , Pp 281-284 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2467-981X |
| DOI: |
10.1016/j.cnp.2021.10.004 |
| Popis: |
Background: Levetiracetam (LEV) is widely used for treatment of focal and myoclonic seizures, but reports of LEV toxicity are scarce. Here, we report a rare case of multifocal myoclonus due to LEV toxicity in a patient with chronic renal insufficiency. Case presentation: A 52-year-old woman with history of chronic kidney disease was admitted to the ICU for sedation and intubation after a cardiac arrest. She developed nonconvulsive status epilepticus that resolved after administration of propofol while receiving LEV 1500 mg twice a day. After holding the propofol infusion, the patient started having multifocal myoclonic jerks, documented on video-EEG recordings with a supratherapeutic level of LEV. After discontinuation of LEV, the myoclonus resolved. Conclusion: This is a unique manifestation of LEV toxicity, which has been scarce in the literature. It suggests an inverted U-shaped dose–response of the antimyoclonic effect of LEV. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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