Improved first trimester maternal iodine status with preconception supplementation: The Women First Trial

Autor: Amy E. Young, Jennifer F. Kemp, Charis Uhlson, Jamie L. Westcott, Sumera A. Ali, Sarah Saleem, Ana Garcès, Lester Figueroa, Manjunath S. Somannavar, Shivaprasad S. Goudar, K. Michael Hambidge, Audrey E. Hendricks, Nancy F. Krebs, the Women First Preconception Maternal Nutrition Trial Group
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Maternal and Child Nutrition, Vol 17, Iss 4, Pp n/a-n/a (2021)
Druh dokumentu: article
ISSN: 1740-8709
1740-8695
DOI: 10.1111/mcn.13204
Popis: Abstract Maternal iodine (I) status is critical in embryonic and foetal development. We examined the effect of preconception iodine supplementation on maternal iodine status and on birth outcomes. Non‐pregnant women in Guatemala, India and Pakistan (n ~ 100 per arm per site) were randomized ≥ 3 months prior to conception to one of three intervention arms: a multimicronutrient‐fortified lipid‐based nutrient supplement containing 250‐μg I per day started immediately after randomization (Arm 1), the same supplement started at ~12 weeks gestation (Arm 2) and no intervention supplement (Arm 3). Urinary I (μg/L) to creatinine (mg/dl) ratios (I/Cr) were determined at 12 weeks for Arm 1 versus Arm 2 (before supplement started) and 34 weeks for all arms. Generalized linear models were used to assess the relationship of I/Cr with arm and with newborn anthropometry. At 12 weeks gestation, adjusted mean I/Cr (μg/g) for all sites combined was significantly higher for Arm 1 versus Arm 2: (203 [95% CI: 189, 217] vs. 163 [95% CI: 152, 175], p
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