| Autor: |
Stephen H-F Macdonald, Elliott Woodward, Michelle M Coleman, Emma R Dorris, Parthiban Nadarajan, Wui-Mei Chew, Anne-Marie McLaughlin, Joseph Keane |
| Jazyk: |
angličtina |
| Rok vydání: |
2012 |
| Předmět: |
|
| Zdroj: |
PLoS ONE, Vol 7, Iss 6, p e38488 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0038488 |
| Popis: |
BACKGROUND: Depletion of T cells following infection by Mycobacterium tuberculosis (Mtb) impairs disease resolution, and interferes with clinical test performance that relies on cell-mediated immunity. A number of mechanisms contribute to this T cell suppression, such as activation-induced death and trafficking of T cells out of the peripheral circulation and into the diseased lungs. The extent to which Mtb infection of human macrophages affects T cell viability however, is not well characterised. METHODOLOGY/PRINCIPAL FINDINGS: We found that lymphopenia ( |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
