| Autor: |
Ahmed Chetouani, Mohammad B. Chawki, Gabriela Hossu, Anna Kearney-Schwartz, Florence Chauveau-Beuret, Serge Bracard, Veronique Roch, Vincent Lebon, Pierre-Yves Marie, Athanase Benetos, Laure Joly, Antoine Verger |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 17, Iss , Pp 804-810 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2017.12.024 |
| Popis: |
Mild cognitive impairment and Alzheimer's dementia involve a grey matter disease, quantifiable by 18F-Fluorodeoxyglucose positron emission tomography (FDG-PET), but also white matter damage, evidenced by diffusion tensor magnetic resonance imaging (DTI), which may play an additional pathogenic role. This study aimed to determine whether such DTI and PET variations are also interrelated in a high-risk population of older hypertensive patients with only subjective memory complaints (SMC).Sixty older hypertensive patients (75±5years) with SMC were referred to DTI and FDG-PET brain imaging, executive and memory tests, as well as peripheral and central blood pressure (BP) measurements. Mean apparent diffusion coefficient (ADCmean) was determined in overall white matter and correlated with the grey matter distribution of the metabolic rate of glucose (CMRGlc) using whole-brain voxel-based analyses of FDG-PET images.ADCmean was variable between individuals, ranging from 0.82 to 1.01.10−3mm2sec−1, and mainly in relation with CMRGlc of areas involved in Alzheimer's disease such as internal temporal areas, posterior associative junctions, posterior cingulum but also insulo-opercular areas (global correlation coefficient: −0.577, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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