Accumulated exposure to high non-high-density lipoprotein cholesterol increases the risk of cardiovascular diseases in hypertensive individuals: An 11-year prospective cohort study
| Autor: | Weiqiang Wu, Yanjuan Chen, Kuangyi Wu, Huancong Zheng, Guanzhi Chen, Xianxuan Wang, Zegui Huang, Zefeng Cai, Zhiwei Cai, Zhichao Chen, Yulong Lan, Shuohua Chen, Shouling Wu, Youren Chen |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Clinical and Experimental Hypertension, Vol 45, Iss 1 (2023) |
| Druh dokumentu: | article |
| ISSN: | 1064-1963 1525-6006 10641963 |
| DOI: | 10.1080/10641963.2023.2264540 |
| Popis: | Background The relationship of cumulative non high-density lipoprotein-cholesterol (Cum-non-HDL-C) concentration with the risk of cardiovascular disease (CVD) in individuals with hypertension remains unclear. Methods In total 27 234 participants for whom three consecutive total cholesterol and HDL-C concentrations were available, and who did not have CVD, comprising 13 617 with hypertension and 13 617 without from 2006 to 2010. Participants were placed into four groups according to Cum-non-HDL-C. Cox proportional hazards models were used to evaluate the relationship between Cum-non-HDL-C and the risk of CVD. Results Over a median 11 years, 1,298 participants with hypertension developed CVD. After adjustment for multiple potential confounding factors, compared with participants with hypertension and Cum-non-HDL-C |
| Databáze: | Directory of Open Access Journals |
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