| Autor: |
Yue Shi, Hui Shi, David C. Nieman, Qiongyi Hu, Luyu Yang, Tingting Liu, Xiaofeng Zhu, Hongzhan Wei, Die Wu, Fei Li, Yanqiu Cui, Peijie Chen |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Frontiers in Physiology, Vol 10 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1664-042X |
| DOI: |
10.3389/fphys.2019.00709 |
| Popis: |
Lactic acid (LA) is a sensitive indicator of exercise intensity and duration. A single bout of prolonged and intensive exercise can cause transient immunosuppression through the interaction of cellular, humoral, and hormone factors. Exercise-induced influences on neutrophil extracellular traps (NETs) release have been reported, but the underlying mechanism is unknown. This study investigated NETs release, cell-free DNA (cf-DNA), and LA concentration in mice after 60 and 145 min of intensive, graded treadmill running. The concentration of LA and cf-DNA increased, while the level of myeloperoxidase-DNA (MPO-DNA) (an indicator of NETs release) decreased during 145 min of exhaustive running. LA was positively and negatively correlated with cf-DNA and MPO-DNA (R2 = 0.57 and 0.53, respectively, both p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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