| Autor: |
Xingxing Cai, Yichen Shen, Yuli Yang, Wei Wang, Li Qian, Jing Cai, Runmin Chi, Shunxuan Yu, Keke Li, Zhixing Wei, Taizhong Chen, Yudong Fei, Yaqin Han, Xiu Chen, Ming Liu, Yifei Liu, Dengbin Wang, Mawei Jiang, Yi‐Gang Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 16 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2047-9980 |
| DOI: |
10.1161/JAHA.120.020068 |
| Popis: |
Background We have previously reported the feasibility of noninvasive stereotactic body radiotherapy (SBRT) as a novel approach for renal denervation. Methods and Results Herein, from a translational point of view, we assessed the antihypertensive effect and chronological evolution of SBRT‐induced renal nerve injury within 6 months in a hypertensive swine model. Hypertension was induced in swine by subcutaneous implantation of deoxycorticosterone acetate pellets in combination with a high‐salt diet. A single dose of 25 Gy with SBRT was delivered for renal denervation in 9 swine within 3.4±1.0 minutes. Blood pressure levels at baseline and 1 and 6 months post‐SBRT were comparable to control (n=5), whereas renal norepinephrine was significantly lower at 6 months (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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