| Autor: |
Wenshuai Liu, Litao Jia, Sichun Zhao, Yue Ma, Siyu Liu, Qian Wang, Xiaoyan Lv, Haiyue Jiang, Xia Liu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nano Select, Vol 3, Iss 11, Pp 1537-1547 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2688-4011 |
| DOI: |
10.1002/nano.202200117 |
| Popis: |
Abstract Bacterial infection can cause delay in wound healing, and reactive oxygen species (ROS) was accumulated in wounds, which threaten patients’ lives. Therefore, it needs to develop a multifunctional hydrogel for infected wound healing. Here, a multifunctional QAS‐CS@GA‐GM hydrogel with antibacterial and antioxidant property, established by the self‐adaptive covalent bond, is prepared aiming to eradicate bacteria and eliminate ROS. It is observed that QAS‐CS@GA‐GM hydrogel displays remarkable ability of clearing ROS and killing bacteria in vitro. With its antibacterial and antioxidant activity, QAS‐CS@GA‐GM hydrogel significantly accelerates the MRSA‐infected wound closure and reduces inflammatory, when QAS‐CS@GA‐GM hydrogel was applied to wound sites. Collectively, the research suggests that a self‐adaptive QAS‐CS@GA‐GM hydrogel is a promising wound dressing as antibacterial and ROS‐scavenging dressing for bacterial‐infected wound. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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