Analysis of the Effect of Nine Consecutive Years’ Intensive Management and Number of Times Achieving the Target Control on Endpoint Events in T2DM Patients in Sanlitun Community Health Service Center in Beijing

Autor: Chen-Mei Zhao, Xue-Li Cui, Gang Wan, Yu-Zhe Lu, Yu-Qin Niu, Cheng-Yu Su, Shuo Cao, Guan-Xiu Liang, Hong-Wei Chen, Jing Li, Xia Lu, Zhi-Yun Deng, Xue-Hui Yu, Wen-Xia Yang, Jian-Hua Li, Hua Fan, Mao-Xia Yang, Yan Fu, Su-Ping Wei, Zhi-Na He, Xue-Lian Zhang, Shen-Yuan Yuan
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: International Journal of Endocrinology, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 1687-8337
1687-8345
DOI: 10.1155/2020/3646342
Popis: Objective. To investigate the effect of intensive management and achieving the target control more than 3 times on endpoint events during 9 consecutive years’ annual assessment in type 2 diabetes (T2DM) patients in the Sanlitun Community Health Service Center in Beijing, including blood glucose, blood pressure, lipids profiles, and the joint target control. Methods. In Beijing Community Diabetes Study (BCDS), 224 patients with T2DM from the Sanlitun Community Health Service Center were enrolled in 2008. All patients were randomly assigned to the intensive management group (n = 113) and the standard management group (n = 111). All patients were followed up for nine consecutive years from January 2009 to December 2017. Systolic blood pressure (SBP), diastolic blood pressure (DBP), glycosylated hemoglobin (HbA1c), and low-density lipoprotein cholesterol (LDL-C) were detected as the main indexes, and the endpoint events were also carried out at the same time. The endpoint events were analyzed by using survival analysis (Kaplan–Meier method) based on management grouping and whether achieving the target control more than 3 times or not. Results. During the nine-year follow-up, the abscission number was 35 (14.29%), among which 14 (12.39%) was in the intensive management group and 21 (18.92%) was in the standard management group. The incidence of diabetic retinopathy (6 cases, 5.41%) and diabetic nephropathy (13 cases, 11.71%) in the standard management group was significantly higher than that in the intensive management group (1 case, 0.88%; 5 cases, 4.42%), respectively (P0.05). All-cause death was 23 cases, in which patients who achieved the target control (HbA1c and LDL-C) and the joint target control more than 3 times were significantly lower than that of less than 3 times (P0.05). There were less incidence of new onset cerebrovascular events, stenosis or occlusion of large arteries, and diabetic microvascular complications in patients who achieved target control (HbA1c and LDL-C) and the joint target control more than 3 times than those with target control less than 3 times (P
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