Elevated microglial oxidative phosphorylation and phagocytosis stimulate post-stroke brain remodeling and cognitive function recovery in mice

Autor: Shanshan Song, Lauren Yu, Md Nabiul Hasan, Satya S. Paruchuri, Steven J. Mullett, Mara L. G. Sullivan, Victoria M. Fiesler, Cullen B. Young, Donna B. Stolz, Stacy G. Wendell, Dandan Sun
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02984-4
Popis: Song et al. use transgenic mice lacking the Na/H exchanger specifically in microglia to show that microglial oxidative phosphorylation plays a key role in post-stroke brain tissue repair and cognitive recovery. Their data is suggestive of a microglial metabolism signaling pathway that could constitute a potential therapeutic target in the context of stroke.
Databáze: Directory of Open Access Journals
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