Mapping of potential neurogenic niche in the human temporal lobe
| Autor: | Adriano Barreto Nogueira |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Arquivos de Neuro-Psiquiatria, Vol 72, Iss 10, Pp 820-820 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1678-4227 0004-282X |
| DOI: | 10.1590/0004-282X20140121 |
| Popis: | The subgranular zone (SGZ) of the dentate gyrus and the subventricular zone (SVZ) are known neurogenic niches in adult mammals. Nonetheless, the existence of neurogenic niches in adult humans is controversial. We hypothesized that mapping neurogenic niches in the human temporal lobe could clarify this issue. Neurogenic niches and neurogenesis were investigated in 28 temporal lobes via immunostaining for nestin and doublecortin (DCX), respectively. Nestin was observed in a continuous layer formed by the SVZ, the subpial zone of the medial temporal lobe and the SGZ, terminating in the subiculum. In the subiculum, remarkable DCX expression was observed through the principal efferent pathway of the hippocampus to the fimbria. A possible explanation for the results is that the SVZ, the subpial zone of the medial temporal lobe and the SGZ form a unit containing neural stem cells that differentiate into neurons in the subiculum. Curiously, the area previously identified as the human rostral migratory stream may in truth be the fornix, which contains axons that originate in the subiculum. This study suggests that neurogenesis may occur in an orchestrated manner in a broad area of the human temporal lobe. |
| Databáze: | Directory of Open Access Journals |
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