Successful management of chromoblastomycosis utilizing conventional antifungal agents and imiquimod therapy

Autor: Jinjin Zheng, Shougang Liu, Zhenmou Xie, Yangxia Chen, Liyan Xi, Hongfang Liu, Yinghui Liu
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Annals of Clinical Microbiology and Antimicrobials, Vol 23, Iss 1, Pp 1-5 (2024)
Druh dokumentu: article
ISSN: 1476-0711
DOI: 10.1186/s12941-024-00718-y
Popis: Abstract Chromoblastomycosis (CBM), a chronic fungal infection affecting the skin and subcutaneous tissues, is predominantly caused by dematiaceous fungi in tropical and subtropical areas. Characteristically, CBM presents as plaques and nodules, often leading to scarring post-healing. Besides traditional diagnostic methods such as fungal microscopy, culture, and histopathology, dermatoscopy and reflectance confocal microscopy can aid in diagnosis. The treatment of CBM is an extended and protracted process. Imiquimod, acting as an immune response modifier, boosts the host’s immune response against CBM, and controls scar hyperplasia, thereby reducing the treatment duration. We present a case of CBM in Guangdong with characteristic reflectance confocal microscopy manifestations, effectively managed through a combination of itraconazole, terbinafine, and imiquimod, shedding light on novel strategies for managing this challenging condition.
Databáze: Directory of Open Access Journals