| Autor: |
Tung-Pin Su, Tsu-Jen Kuo, San-Nan Yang, Gene-Hsiang Lee, Yen-Tung Lee, Yi-Chen Wang, Jih-Jung Chen, Zhi-Hong Wen, Tsong-Long Hwang, Ping-Jyun Sung |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Marine Drugs, Vol 18, Iss 4, p 183 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1660-3397 |
| DOI: |
10.3390/md18040183 |
| Popis: |
Two 11,20-epoxybriaranes, including a known compound, juncenolide K (1), as well as a new metabolite, fragilide X (2), have been isolated from gorgonian Junceella fragilis collected off the waters of Taiwan. The absolute configuration of juncenolide K (1) was determined by single-crystal X-ray diffraction analysis for the first time in this study and the structure, including the absolute configuration of briarane 2 was established on the basis of spectroscopic analysis and compared with that of model compound 1. One aspect of the stereochemistry of the known compound 1 was revised. Briarane 2 was found to enhance the generation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7 cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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