| Autor: |
Daniel Paech, Moritz Zaiss, Jan-Eric Meissner, Johannes Windschuh, Benedikt Wiestler, Peter Bachert, Jan Oliver Neumann, Philipp Kickingereder, Heinz-Peter Schlemmer, Wolfgang Wick, Armin Michael Nagel, Sabine Heiland, Mark Edward Ladd, Martin Bendszus, Alexander Radbruch |
| Jazyk: |
angličtina |
| Rok vydání: |
2014 |
| Předmět: |
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| Zdroj: |
PLoS ONE, Vol 9, Iss 8, p e104181 (2014) |
| Druh dokumentu: |
article |
| ISSN: |
1932-6203 |
| DOI: |
10.1371/journal.pone.0104181 |
| Popis: |
Background and purposeNuclear Overhauser Enhancement (NOE) mediated chemical exchange saturation transfer (CEST) is a novel magnetic resonance imaging (MRI) technique on the basis of saturation transfer between exchanging protons of tissue proteins and bulk water. The purpose of this study was to evaluate and compare the information provided by three dimensional NOE mediated CEST at 7 Tesla (7T) and standard MRI in glioblastoma patients.Patients and methodsTwelve patients with newly diagnosed histologically proven glioblastoma were enrolled in this prospective ethics committee-approved study. NOE mediated CEST contrast was acquired with a modified three-dimensional gradient-echo sequence and asymmetry analysis was conducted at 3.3 ppm (B1 = 0.7 µT) to calculate the magnetization transfer ratio asymmetry (MTR(asym)). Contrast enhanced T1 (CE-T1) and T2-weighted images were acquired at 3T and used for data co-registration and comparison.ResultsMean NOE mediated CEST signal based on MTR(asym) values over all patients was significantly increased (pConclusionNOE mediated CEST Imaging at 7 T provides additional information on the structure of peritumoral hyperintensities in glioblastoma and displays isolated high intensity regions within the CE-T1 tumor that cannot be acquired on CE-T1 or T2-weighted images. Further research is needed to determine the origin of NOE mediated CEST and possible clinical applications such as therapy assessment or biopsy planning. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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