| Autor: |
Ioana M. A. Samfira, Aristea S. Galanopoulou, Hiroki Nariai, Jonathan M. Gursky, Solomon L. Moshé, Berj L. Bardakjian |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Epilepsia Open, Vol 9, Iss 1, Pp 122-137 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2470-9239 |
| DOI: |
10.1002/epi4.12831 |
| Popis: |
Abstract Objective Infantile epileptic spasms (IS) are epileptic seizures that are associated with increased risk for developmental impairments, adult epilepsies, and mortality. Here, we investigated coherence‐based network dynamics in scalp EEG of infants with IS to identify frequency‐dependent networks associated with spasms. We hypothesized that there is a network of increased fast ripple connectivity during the electrographic onset of clinical spasms, which is distinct from controls. Methods We retrospectively analyzed peri‐ictal and interictal EEG recordings of 14 IS patients. The data was compared with 9 age‐matched controls. Wavelet phase coherence (WPC) was computed between 0.2 and 400 Hz. Frequency‐ and time‐dependent brain networks were constructed using this coherence as the strength of connection between two EEG channels, based on graph theory principles. Connectivity was evaluated through global efficiency (GE) and channel‐based closeness centrality (CC), over frequency and time. Results GE in the fast ripple band (251–400 Hz) was significantly greater following the onset of spasms in all patients (P central > anterior, Kruskal‐Wallis P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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